A Pre-Post Study to Evaluate the Antimicrobial Effect of Dhoopana with Nimbapathradi Choorna in Dushtavrana (Non-Healing Venous Ulcer)

Abstract

An ulcer is a break in the continuity of the covering epithelium of skin or mucous membrane. Non healing ulcers are defined as those that do not follow the normal healing process and show no signs of healing in 4weeks. One of the primary reasons for delayed healing in ulcers is microbial infection. Chronic or non-healing ulcers are often colonized by a diverse range of microorganisms, making the wound environment polymicrobial. These bacteria can release various inflammatory mediators that interfere with the natural wound healing process by prolonging the inflammatory phase and impeding tissue regeneration. The widespread emergence of antibiotic-resistant strains has further complicated the management of such wounds, reducing the effectiveness of conventional antimicrobial therapies. This study is done to evaluate the antimicrobial effect of Dhoopana with Nimbapathradi choornam in non-healing venous ulcer by assessing the microbial load. This is a pre and post clinical trial with 25 participants in a single group selected on the basis of inclusion and exclusion criteria. Dhoopana with Nimbapathradi choorna was applied for 10 days, twice daily, for 10 minutes. Nimbapathradi choorna is explained in Vrana Shodhadhikara chapter of Bhavaprakasha madhyama khanda. After the study period, there was significant reduction in the load of micro-organism noted.