Effect of Trikatvadi Gudika Along with Gokshura Kwatha in the Management of Benign Prostatic Hyperplasia – A Pre Post Study

Abstract

Benign Prostatic Hyperplasia (BPH) is a non-malignant enlargement of the prostate gland leading to lower urinary tract symptoms (LUTS) in aging men. Conventional management involves alpha-blockers, 5-alpha reductase inhibitors and surgical procedures such as TURP, each with limitations and side effects. In Ayurveda, BPH can be correlated to Mutraghata, specifically Mutragranthi and Vatashteela, characterized by obstruction to urine flow and enlargement in the prostatic region. There are various Yogas mentioned for Mutraghata in Ayurvedic classics. One among them is administration of Trikatvadi Gudika along with Gokshura Kwatha which is explained in Mutrakrichradhikara of Bhavaprakasa. Objectives: To evaluate the effect of Trikatvadi Gudika along with Gokshura Kwatha in the management of Benign Prostatic Hyperplasia. Materials and Methods: An interventional single-arm open clinical trial was conducted in 25 male participants aged 41–75 years diagnosed with BPH based on clinical and ultrasonographic criteria. Patients were administered Trikatvadi Gudika (1.5 g) along with Gokshura Kwatha (48ml) and 6ml honey as Anupana, twice daily before food for 30 days. Follow-up was done for 30 days after treatment period. Assessment parameters included International Prostate Symptom Score (IPSS), prostate volume and post-void residual urine (PVRU). Data were analyzed using Wilcoxon signed-rank test and paired t test. Results: Significant reductions were observed in mean IPSS score, mean prostate volume and mean PVRU and no adverse effects were reported. Conclusion: Trikatvadi Gudika along with Gokshura Kwatha is effective and safe in reducing prostate enlargement and LUTS in BPH, highlighting a cost-effective conservative management option.