Integrating Rasayana Therapy in Cardiovascular Disease Management: A Review of Preclinical - Clinical Evidences and Possible Mechanism of Action

Abstract

Cardiovascular diseases are one of the major causes for mortality in the current era. The means and mechanisms to reduce the myocardial damage are known as cardio protection. There is need for pharmacological agents that can activate the repair and regeneration of myocardium. Rasayanas of Ayurveda are widely studied for their regenerative and tissue repair potential. The present work focuses on the relevance and scope of Rasayana for the management of cardiovascular diseases. The classical Ayurveda textbooks and relevant modern research works were considered. There are Rasayana drugs mentioned in Ayurveda which were indicated in Hridroga and cardioprotective effect of some were proven through preclinical studies. The antioxidant, adaptogenic and lipid lowering effect of different Rasayanas were responsible for its cardioprotective effect. Rasayana drugs can contribute significantly for the cardiovascular disease management by virtue of its regeneration and repair potential. Even though there are supportive preclinical evidences, extensive clinical trials are necessary to evaluate its safety and efficacy in humans.