Incorporating Dushivishajanya Rogas to Autoimmune Skin Disorders- Breaking the Cell Membrane Impermeability - A Conceptual Study

Abstract

Vagbhata described Dushi visha as a type of Visha, which do not have the combination of all gunas to create immediate toxicity in the body. For instance, it is the Visha which is not that Vyavayi, Vikashi and Sookshma, so it cannot spread quickly. Instead, they create a ‘Leena visha’ Avastha (dormant stage) in the body, lodging somewhere in the body because the gunas are not potent enough to destroy the Ojas immediately, but can affect it eventually. These toxins reside in the body, where they have affinity, and get covered by Kapha over the period. They can reside anywhere in the body where their affinity matches (owing to Samanya vishesha sidhanta). They can reside in Amasaya causing Kaphavata rogas and in Pakvasaya causing Vatapitha rogas. They can reside in Dhatus, from Rasa, Rakta to Sukra. Even in the Leena Avastha, they can cause disturbances in the body mentioned as Dushi visha poorvarupa by Sushrutha Acharya like more of sleep, feeling of heaviness of body, more of yawning, looseness of joints, tingling or diffuse pain in the body. The concept ‘Kaphavrtham Varshagananubhanthi” (covered by Kapha, it remains in the body), can be corelated with toxins being depositing on the protein receptors of the cell membrane, causing protein receptor modification, and breaking its permeability gradually. Toxins enter the cell wall to nucleus and DNA, and cause genetic mutation. Ultimately, the cell loses its structure and function. The function that cell has been doing will be abrupted and this gives rise to many diseases especially autoimmune diseases, because when the cell loses its self-intolerance, it can’t distinguish between self and outside. The study focuses on incorporating Dushivisha with autoimmune skin diseases by comparing both of their pathogenesis.