Meta‑Analysis of Amavata and its Most Effective Treatment Protocols in Ayurveda

Abstract

Amavata, a chronic inflammatory disorder described in Madhava Nidana, resembles rheumatoid arthritis clinically and pathogenetically due to Vata accumulation and Ama presence. Ayurvedic interventions- including Simhanada Guggulu, various Panchakarma treatments like Vaitarana Basti, Kshara Basti, Niruha Basti, Virechana and Rasayana have been studied across 28 authenticated clinical and observational reports. This meta-analysis evaluates the efficacy of these interventions in reducing inflammatory markers (ESR, CRP), pain, stiffness, and swelling, with attention to Prakṛuti-specific responses when documented. Results indicate that Simhanada Guggulu was the most frequently employed internal agent, and Panchakarma, particularly Vaitarana and Niruha Basti, produced significant improvements in objective measures. Case reports reveal Prakṛuti influences: Kapha-Vata patients responded best to Vaitarana and Niruha Basti. Rasayana regimens helped maintain long-term benefits. While sample sizes varied widely, consistent trends support a combined Shamana and Shodhana-based management tailored to individual Prakṛuti. The findings offer a validated, evidence-based approach for practitioners and align with classical Ayurvedic principles.