International Journal of Ayurveda and Pharma Research <div align="justify"> <p class="para1"><strong>International Journal of Ayurveda and Pharma Research (IJAPR)</strong>&nbsp;is an international peer reviewed Monthly open access Online and Print journal. The aim of the journal is to increase the impact of research in both academic and industry, with strong emphasis on quality and originality. The journal promotes to publish the articles in the field of&nbsp;<strong>Ayurveda, Siddha, Yoga, Naturopathy, Unani, Homeopathy and Allopathy</strong>&nbsp;systems of medicine and Pharmaceutical Sciences. Researchers may submit (1). Original Research Articles (2). Review articles (3). Book Reviews (4). Short Communications/ Research Letter (5). Case Report (6). Letter to the Editor/Correspondence.</p> </div> Mahadev Publications en-US International Journal of Ayurveda and Pharma Research 2322-0902 Evaluation of In Vitro and In Vivo Antioxidant Potential of the Ethyl Acetate Fraction of Cyperus Pangorei Rhizome <p><strong>Background and Aim:</strong> Antioxidants derived from natural sources, particularly those rich in flavonoids and phenolic compounds, have attracted considerable interest for their potential health benefits in combating oxidative stress-related diseases. This study aimed to evaluate the antioxidant potential of the ethyl acetate (EtAc) fraction obtained from <em>Cyperus pangorei</em> rhizome, focusing on both in vitro and in vivo assessments. <strong>Methods: </strong>The EtAc fraction was subjected to RP-HPLC analysis to identify and quantify phenolic compounds and flavonoids. Acute toxicity testing was performed to assess the safety profile of the EtAc fraction. In vitro antioxidant activity was determined using DPPH and ABTS+ radical scavenging assays. In vivo evaluation of antioxidant activity was conducted in Triton X-100-induced oxidative stress model in mice, measuring malondialdehyde (MDA) content, glutathione (GSH) levels, and superoxide dismutase (SOD) activity in liver tissues. <strong>Results: </strong>RP-HPLC analysis confirmed the presence of quercetin, luteolin, and apigenin in the EtAc fraction. The fraction exhibited significant dose-dependent antioxidant activity in both DPPH and ABTS+ assays, with IC50 values indicating potent scavenging effects. In the Triton X-100-induced stress model, administration of the EtAc fraction led to a reduction in MDA levels, restoration of GSH levels, and enhancement of SOD activity in mouse liver tissues. <strong>Conclusion:</strong> The findings suggest that the EtAc fraction from <em>C. pangorei</em> possesses promising antioxidant properties, as evidenced by its ability to mitigate oxidative stress-related damage both in vitro and in vivo.</p> Biswajit Samanta S. K. Gupta Amal K. Maji Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 1 8 10.47070/ijapr.v12i3.3152 Ayurvedic Approach for Management of Secondary Infertility due to Artavakshaya (PCOD) <p>The World Health Organization defines infertility as a disorder of the male or female reproductive system characterized by the inability to conceive after 12 months or more of consistent unprotected sexual activity. Secondary infertile if they have successfully became pregnant at least once in the past. 30-40% of infertility is caused by ovulatory disruption. PCOS is characterized by oligo/anovulation, excess androgen-related symptoms, and numerous ovarian cysts. Infertility correlates with <em>Vandhyatha</em> in Ayurveda. Acharya Harita described that failure to achieve a <em>Praja</em> known as <em>Vandhayatwa.</em> <em>Praja</em> is achieve by <em>Garbha</em> and to achieve <em>Garbha </em>purity of many component (<em>Ritu, Kshetra, Ambu, Beeja</em>) is necessary. Regarding this case, <em>Ritu </em>is disturbed in form of <em>Artavkshaya</em>, managed through principles like use of <em>Agneya dravya</em>, <em>Agni Deepana</em>, <em>Vata Shamana</em> and <em>Piita Vardhna.</em> <strong>Case presentation:</strong> A female patient, 25 years old, visited Prasuti Tantra and Stri- Roga OPD of National Institute of Ayurveda, Jaipur, on 28 august 2023 with secondary infertility associated with delayed and scanty menses for 3 years. <strong>Methodology: </strong>Detailed history with all clinical, physical examination and laboratory investigations were carried out which were normal. Ultrasonography reveals bilateral PCOD. So the treatment was planned accordingly. Patient was treated with <em>Shatapushpa churna</em> in 2 consecutive cycles. <strong>Result: </strong>Patient got her menstruation after one month of drug intake with improvement in menstrual pattern. She continued to take drug during the second month and missed her period consequently after that.UPT was done and was found positive</p> Nikita Bharghava Bihani Sanjyal K. Bharathi Poonam Choudhary Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 9 13 10.47070/ijapr.v12i3.3157 Extraction and Analytical Study of Semecarpus Anacardium L. Seed Oil <p><em>Bhallataka</em>, also known as the marking nut or dhobi nut, is a potent ingredient in Ayurvedic medicine. Despite its irritant nature, it's been used for centuries to treat a myriad of diseases. Its oil, extracted using the <em>Patala Yantra</em>, is a key formulation in Ayurvedic pharmaceutics. Ayurveda, the ancient Indian system of medicine, is gaining global recognition for its holistic and natural approach to health. A significant part of Ayurvedic treatments are plant-based, ranging from raw plant materials to refined extracts. One such plant is <em>Semecarpus anacardium</em> <em>Linn</em>, the botanical source of <em>Bhallataka</em>. The plant is being traditionally used by the ancient healers in clinical practice. Apart from the clinical uses the plant was also used for marking clothes, as hair dyes and in many non-therapeutic uses as well. <em>Bhallataka</em> is a plant which holds much significance in Siddha and Unani system of medicine. Various studies have been conducted to understand its physical and chemical nature of the plant, in order to understand its use in therapeutic purposes. Chemical and phytochemical analysis of <em>Bhallataka </em>nut reveals a treasure trove of bioactive compounds- biflavonoids, phenolic compounds, bhilawanols, minerals, vitamins, and amino acids. These compounds make <em>Bhallataka</em> effective against various diseases like arthritis, tumors, and infections. The oil of <em>Bhallataka</em>, extracted using the <em>Patala Yantra</em> method, is particularly noteworthy. This oil is an integral part of Ayurvedic pharmaceutics, and its application is referenced in various ancient texts.</p> Parinita Kaundal Sanjeev kumar Ranote Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 14 16 10.47070/ijapr.v12i3.3162 Pemphigus Foliaceous with special reference to Visphota Kushta <p>Pemphigus is an autoimmune blistering disease which can be fatal if left untreated. In case of secondarily infected skin lesions, life threatening sepsis may develop. There is no specific treatment protocol for the management of pemphigus. The present study is aimed to treat a 57-year-old male patient clinically diagnosed with pemphigus foliaceus admitted in Kayachikitsa department in Govt. Ayurveda College, Thiruvananthapuram. Treatment was aimed at controlling the progression of disease, preventing infection and inducing healing of the affected area. In Ayurveda symptoms are more similar to<em> Kaphapitha kushta</em> especially <em>Visphota kushta</em>. <em>Langhana, Snehapana</em> and repeated <em>Sodhana</em> were the treatment protocols adopted. Ayurvedic approach in this single case of pemphigus is beneficial in correcting the inherent <em>Agnimandya</em> at <em>Koshta</em> and <em>Dhatu</em> level and thus provides significant result. PDAI score was used for assessment. Before treatment PDAI was 96, reduced to 24 after <em>Sodhana</em> and after treatment it was 6. There was no recurrence of symptoms after 2 weeks.</p> K Ambika Aswathy Dev S Vishnu P Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 17 21 10.47070/ijapr.v12i3.3175 Trividha Anushastra Karma in Netraroga <p><em>Shalakya tantra</em>, also known as <em>Uttamanga Chikitsa,</em> focuses on the vital sense organs situated above the <em>Jatru</em>-clavicle, addressing diseases of the head (<em>Shiras</em>), ear (<em>Karna</em>), eye (<em>Netra</em>), throat (<em>Kanta</em>), and nose (<em>Nasa</em>). The eye is considered as very important part of the body which performs the work of vision and due to its sensitive nature, it needs great care. Acharya Sushrutha outlines four treatment methods like <em>Bheshaja, Shastra, Kshara</em> and <em>Agni</em> <em>karma</em> as important treatment modalities. <em>Anushastra karma</em> are the para-surgical procedures, entail performing surgical interventions without the use of <em>Shastras</em> - sharp surgical instruments. Acharya Sushrutha has mentioned 14 types of <em>Anushastras</em> among which <em>Jalaukavacharana</em>, <em>Agnikarma</em> and <em>Ksharakarma</em> are given more importance and described in detail. Due to the <em>pradhanyatwa</em> of these three procedures in treatment they are also known as <em>Trividha Anushastra karma.</em> Along with <em>Vata</em>, <em>Pitta</em> and <em>Kapha doshas, Rakta</em> also plays a major role in causing different <em>Netra rogas.</em> So, it is advisable to go for safest <em>Raktamokshana</em> to do <em>Dushita rakta dosha nirharana</em>. In this article, an attempt is made to elaborate the complete knowledge of <em>Anushastras</em> used in different <em>Netra rogas</em> mentioned by our <em>Acharyas</em>. These procedures are simple, less time consuming, non-invasive, safe and cost-effective.</p> Harshitha. M Chaitra Shree. S Prakruthi. G Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 22 27 10.47070/ijapr.v12i3.3176 Evaluating the Efficacy and Safety of Eye Mantra Drops: A Comprehensive Post-Marketing Surveillance Study in Ocular Disorders <p><strong>Objectives: </strong>This study aimed to systematically evaluate the efficacy and safety of Eye Mantra Drops, a modern formulation integrating ayurvedic principles and medicinal plant extracts, in addressing various ocular conditions, including conjunctivitis, iritis, dry eyes, eye strain, itchiness, and watery eyes. <strong>Methods: </strong>The study adopted a single-center, open-label, non-randomized, post-marketing surveillance approach, involving 120 subjects with diverse ocular conditions. Eye Mantra Drops, comprising thirteen traditionally used ingredients, were administered to the participants for 7 days. Frequency and severity of symptoms, vital signs, and adverse events were assessed at screening and at the end of study to evaluate the safety and efficacy of Eye Mantra Drops. <strong>Results: </strong>The study revealed a significant reduction in frequency and symptom severity across diverse ocular conditions, including conjunctivitis, iritis, dry eyes, itchiness, watery eyes, and eye strain. No adverse events were reported, and vital signs remained stable, indicating the safety of Eye Mantra Drops. <strong>Conclusion: </strong>Eye Mantra Drops emerged as a promising and well-tolerated intervention for various ocular conditions including conjunctivitis, iritis, dry eyes, eye strain, itchiness, and watery eyes.</p> Shreya Verma Amrish Verma Jaspal Singh Hasan Ali Ahmed Chetan Jaykar Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 28 37 10.47070/ijapr.v12i3.3090 Ayurveda in the Management of Avascular Necrosis of Femoral Head - A Case Report <p>Avascular necrosis (AVN) is defined as cellular death of bone components due to interruption of the blood supply. The bone structures then collapse, resulting in pain, loss of joint function and long-term joint damage. Treatment goals for AVN are to improve the joint, stop the bone damage, and ease pain. In modern science treatment includes NSAIDS, core decompression, bone grafting and total joint arthroplasty which have their own complications, high cost and prognosis is also very poor. In Ayurveda it can be correlated to the <em>Asthi-Majja gatha vata</em>. In this <em>Raktavaha Srotorodha</em> also occur which results in <em>Asthi Dhatu Kshaya</em>. Aim of study is to introduce an alternative therapeutic modality through Ayurveda which help to reduce pain, improve quality of life and prevent further damage of bone which is cost effective as well. The present case report is a single case study of a 32year old female patient who was diagnosed with Stage Ⅱ Avascular Necrosis of bilateral femoral head done at Government Ayurveda College Panchakarma Hospital, Poojappura, Thiruvananthapuram. She was treated with selected <em>Panchakarma</em> treatments and specific <em>Samana oushadhis</em>. There was significant improvement in the symptoms which was assessed using relevant tools like VAS score for pain, goniometer for range of movement and Oxford Hip score for assessment of function and pain in hip. The present case study documents that <em>Panchakarma</em> procedures and <em>Samana oushadhis</em> can be effective in AVN and improve the quality of life of patient.</p> Vineetha Cherian Ambili Krishna Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 38 41 10.47070/ijapr.v12i3.3172 Assessment of Efficacy and Safety of Dr.Ortho Capsules in Managing Musculoskeletal Disorders: A Phase IV Post-Marketing Surveillance Study <p><strong>Objectives: </strong>This study aimed to evaluate the potential efficacy and safety of Dr. Ortho capsules in managing various musculoskeletal conditions, including knee pain, joint stiffness, arthritis, bulky shoulders, joint inflammation, acute sports injuries, strains, and sprains. <strong>Methods: </strong>The study was a single centric, open-label, non-randomized, post-marketing surveillance study involving 120 subjects. Subjects were selected based on inclusion and exclusion criteria. The study assessed changes in pain intensity and disability levels after the administration of Dr. Ortho capsules, employing the Visual Analog Scale (VAS) and Oswestry Disability Index (ODI), respectively. Additionally, safety was evaluated through physical examinations, vital sign monitoring, and laboratory safety parameters.<strong> Results: </strong>The study revealed significant reductions in pain intensity and disability levels among the participants. Pain intensity, as measured by VAS, decreased significantly (p&lt; 0.0001) from a mean score of 4.84 at baseline (day 1) to 0.38 at the end of the study (day 30). Disability levels, indicated by ODI, significantly improved (p&lt;0.0001) from a mean score of 14.73% at baseline to 1.88% at the end of the study. There were no reported adverse events during the study, and all safety parameters remained within normal ranges.<strong> Conclusion: </strong>The findings of the study suggest that Dr. Ortho capsules may offer effective relief for individuals with musculoskeletal conditions, reducing pain intensity and improving functional abilities. The absence of adverse events and the maintenance of normal safety parameters indicate the safety of Dr. Ortho capsules for human consumption.</p> Vijay Kimtata Vishu Gupta Lakhbir Singh Hasan Ali Ahmed Lokesh Holagundi Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 42 48 10.47070/ijapr.v12i3.3089 Ayurvedic Treatment Modalities of Diabetic Peripheral Neuropathy <p>Diabetic peripheral neuropathy is the damage of the nerves due to the uncontrolled diabetes. It can affect any of the neurons can affect any of the neurons. Diabetic distal symmetric sensory and sensorimotor polyneuropathy is the most prevalent type of diabetic neuropathy. The symptoms appear as sensory loss, first in the toes and progressively moving up the legs, fingers, and arms over time. Tingling sensation, Burning sensation, Deep aching pain are other related symptoms. A patient age 54 years with diabetes for past 15 years, hypertension, dyslipidemia, complains of burning sensation of both feet (right&gt;left), numbness, pricking pain, unsteadiness while walking, brownish red discolouration of both lower limbs. The symptoms were gradual in onset. Nerve Conduction Study showed axonal type of motor and sensory affecting peroneal nerve neuropathy. He admitted in Vaidyaratnam Ayurveda College Hospital, done Vibrotherm Neuropathy Analyzer and revealed small and large fibre neuropathy with severe loss of sensations. The main intention of the study is to improve the quality of life of the patient by reducing the symptoms that is disturbing his day today routine. Patient given with anti diabetic Ayurvedic formulations internally. Externally <em>Rookshana, Vatahara, Brimhana</em> treatments were done. After the treatment, Michigan neuropathy screening instrument, diabetic Neuropathy symptom score, Toronto clinical scoring system score were reduced. Neuropathy Analyzer showed mild to moderate loss of sensation. By adopting <em>Prameha hara chikitsa</em> coupled with <em>Vata vyadhihara chikitsa</em>, complications of diabetes can be managed. It is important to focus on diet and regimen since diabetes is a lifestyle disorder and, in ayurveda it is considered as an <em>Anushangi Vyadhi</em>.</p> Lekshmi P S Navaneeth Krishnan N Marikutty T C Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 49 54 10.47070/ijapr.v12i3.3177 Ayurvedic Pharmacology for Mutrakrichra <p><em>Mutrakrichra roga</em> (urinary disorders), is a prevalent ailment described in Ayurveda with diverse aetiologies and manifestations. Managing <em>Mutrakrichra </em>(urinary disorders) involves using various herbal drugs with diuretic, lithotriptic, and soothing properties. This study aims to compile and compare the drugs used in treating <em>Mutrakrichra</em> <em>roga </em>(urinary disorders) from different classical Ayurvedic texts or <em>Samhitas</em>, including <em>Charaka</em> <em>Samhita</em>, <em>Sushruta Samhita, Ashtanga Hridaya</em>, and other manuscripts. A systematic review of these texts was conducted to identify the drugs recommended for managing <em>Mutrakrichra</em> <em>roga</em> (urinary disorders). The findings revealed a rich repository of medicinal plants and formulations used for their therapeutic effects on urinary disorders, including <em>Gokshura (Tribulus terrestris), Punarnava (Boerrhavia diffusa),</em> and many others. This compilation of drugs from different <em>Samhitas</em> provides valuable insights into the traditional knowledge and practices of Ayurveda in managing <em>Mutrakrichra</em> <em>roga</em>. It underscores the need for further research and clinical studies to validate the efficacy and safety of these herbal remedies in contemporary healthcare practices.</p> Sonal Singh Kushwaha Priya Gupta Suman Panwar Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 55 62 10.47070/ijapr.v12i3.3171 Ayurvedic Insights on Improving Poor Sleep Quality <p>Sleep – this natural urge is so essential phenomenon of life that engages our one third of life-span, still indulging in being slept is mystery to everyone. At one side adequate sleep quality imparts fair concentration, emotional, cognitive motivational harmony inside body’s mind, soul and consciousness. Contrary to which inadequate sleep or poor sleep quality leads to tiredness, lack of focus, exhaustion, a low pain tolerance, anxiety, irritational thoughts, hallucinations, loss of appetite, constipation and many more. Sleep has a positive impact over digestion, metabolism, nourishment and health. It is irresistible, irreplaceable and unique boon for us, which is pillar of our life. The natural cycle of sleep and awakening is depending on <em>Awastha</em> of <em>Sharir</em> <em>Dosha</em>, <em>Kaal Dosha</em>, and few more factors as depicted in Ayurveda texts. So, the quality of sleep depends on these factors. If there is <em>Kshaya </em>of<em> Kapha</em>, or <em>Vriddhi</em> of <em>Vata</em> and <em>Pitta</em>, then the quality of sleep disturbs. In the realm of holistic well-being, Ayurveda, the ancient Indian system of medicine, offers profound insights into optimizing sleep quality. Through personalized approaches, Ayurvedic remedies like herbal formulations, lifestyle modifications, and relaxation techniques aim to rebalance <em>Doshas</em> and promote restful sleep. Integrating practices such as meditation, gentle yoga, and consistent sleep routines can pacify <em>Vata </em>and<em> Pitta Dosha</em>, calm the mind, and induce relaxation, fostering deeper and more rejuvenating sleep. Ayurveda's holistic perspective provides a natural and sustainable pathway to address poor sleep quality and promote overall well-being. The present paper is here to discuss in detail about <em>Sukh Nidra</em>.</p> Parul Sharma Ved Bhushan Sharma K.K.Sharma Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 63 67 10.47070/ijapr.v12i3.3150 Role of Yoni Dhadhyakara Lepa in First Degree Uterine Prolapse <p>According to WHO estimation the global occurrence of uterine prolapse is increasing and is assumed to be two to twenty percent. In <em>Ayureda</em> <em>Doshas</em> involved in <em>Prasramsini</em> <em>Yonivyapa</em> is <em>Pitta</em> <em>Pradhan</em> <em>Vata Dosha. </em>So, for the <em>Samprapti Vighatana </em>of <em>Prasramsini Yonivyapada</em> treatment should emphasize mainly on <em>Pitta </em>and <em>Vata Shamana</em>. <em>Acharaya Sushruta</em> has described <em>Prasramsini Yonivyapada</em> in <em>Pittaja Yonivyapada </em>which can be correlated with and first and second degree uterine prolapse. This condition is usually encountered in perimenopausal or postmenopausal period although young age group with distress during labor is not an exemption. A 42 years old female presented with first degree uterine prolapse was treated with <em>Yoni Dhadhyakara Lepa (Madanphala, Madhuyasti, Karpura)</em> followed by <em>Yoniprakshalana </em>with <em>Triphala Kwatha</em>. This treatment was continued for seven days twice daily for three consecutive months with positive outcome and good symptomatic relief in the patient.</p> Pratibha Rana Seema Shukla Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 68 71 10.47070/ijapr.v12i3.3044 Exploring the Anti-Inflammatory Potential of Cyperus pangorei Rhizome Extracts An In Vitro and In Vivo Study <p><strong>Background and aim:</strong> Inflammation is a pivotal process implicated in various physiological and pathological conditions, necessitating the exploration of alternative anti-inflammatory agents with minimal side effects. This study aimed to investigate the anti-inflammatory potential of the standardized ethyl acetate (EtAc) fraction derived from <em>Cyperus pangorei</em> rhizomes. <strong>Methods: </strong>The rhizomes of <em>C. pangorei</em> were collected, processed, and subjected to extraction and fractionation to obtain the EtAc fraction. RP-HPLC analysis was employed to standardized the EtAc fraction against standard quercetin, luteolin, and apigenin. <em>In vitro</em> studies utilized peritoneal macrophages isolated from male Swiss albino rats to assess NO production and cytokine levels (IL-1β, IL-6, TNF-α) upon treatment with the EtAc fraction. <em>In vivo</em> evaluation was conducted using a carrageenan-induced rat paw edema model. <strong>Results: </strong>RP-HPLC analysis revealed the presence of quercetin, luteolin, and apigenin in the EtAc fraction. <em>In vitro</em> studies demonstrated dose-dependent inhibition of LPS-induced NO production and suppression of inflammatory cytokines (IL-1β, IL-6, TNF-α) by the EtAc fraction. Furthermore, in the carrageenan-induced rat paw edema model, the EtAc fraction exhibited dose-dependent inhibition of paw edema. <strong>Conclusion:</strong> The findings of this study highlight the significant anti-inflammatory potential of <em>C. pangorei</em> rhizome extracts, particularly the EtAc fraction. The identified compounds, quercetin, luteolin, and apigenin, contribute to its anti-inflammatory activity by modulating key inflammatory mediators. These results support the potential therapeutic use of <em>C. pangorei</em> in managing inflammation-related disorders. Further research is warranted to elucidate the underlying mechanisms and evaluate the long-term efficacy and safety of <em>C. pangorei</em> extracts as anti-inflammatory agents.</p> Biswajit Samanta S. K. Gupta Amal K. Maji Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 72 78 10.47070/ijapr.v12i3.3155 Pharmaceutico-Analytical Study of Tamboola Arka <p><em>Arka Kalpana</em> is a distinctive Ayuvedic pharmaceutical preparation in which the active principles and volatile components of a drug are extracted with the help of <em>Arka yanthra</em> or another practical modern distillation apparatus. <em>Tamboola Arka</em> is a preparation mentioned in third <em>Shataka</em> of <em>Arka Prakasha</em>. It has properties to cure the <em>Mukha dourgandhya</em>, <em>Mala, Vata</em> and <em>Srama nashana. Tamboola pathra </em>has<em> Katu, Tikta, Kashaya rasa</em> and <em>Laghu, Tikshna Vishada gunas</em> by which it can be used to control the diseases which occur inside the mouth. Since it is an <em>Arka</em> preparation it has got several benefits like shelf life and is also user friendly. No previous works have been carried out on <em>Tamboola Arka</em>. So in this study <em>Tamboola Arka</em> was prepared and organoleptic and physico-chemical parameters were tested. GCMS (Gas Chromatography and Mass Spectrometry) was also conducted to identify the various components and their concentrations.</p> Anjana R A R Rajam Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 79 83 10.47070/ijapr.v12i3.3167 Unraveling the Ayurvedic Protocol in the Management of Ranula <p><em>Shalakya tantra </em>is the branch of Ayurveda which deals with <em>Urdhwajatrugata rogas </em>i.e., diseases occurring in supraclavicular region<em>.</em> <em>Acharyas</em> have mentioned various <em>Mukharogas </em>(diseases pertaining to oral cavity) which are further subdivided into various categories. <em>Acharya Sushruta </em>has mentioned five<em> Jihwagata rogas </em>(diseases of tongue) and their management<em>. Upajihwika </em>which is caused by vitiation of <em>Kapha </em>and<em> Rakta,</em> is the <em>Jihwagraroopa</em> <em>shwathu</em> cystic swelling under the ventral aspect of tongue. In modern, it can be correlated with <em>Ranula</em> which is a translucent swelling in the floor of the mouth formed due to sublingual gland trauma or obstruction of the ducts. It further leads to extravasation and accumulation of saliva in the surrounding tissue thus forming a cyst. Case and Intervention- A 49-year-old male patient presented to ENT OPD of Patanjali Ayurveda Hospital with swelling in left submandibular region for 2 months. There was no difficulty in mastication and swallowing with no history of trauma. The patient was diagnosed with plunging <em>Ranula</em> sized 4x3 cm based on USG findings. He underwent three months and 10 days course of Ayurvedic regime and two follow ups showing reduction in size of the cystic swelling. Conclusion: Several surgical techniques have been introduced to treat <em>Ranula </em>ranging from marsupialization, excision of <em>Ranula</em>, excision of sublingual glands, sclerotherapy with varying success and recurrence rate. Ayurvedic protocol aimed at holistic approach by pacifying the vitiated <em>Doshas</em> and showing marked regression in the cystic growth without making the patient undergo the pain and high cost and adverse effect as that of a surgical procedure.</p> Negi Sangyasri Negi Aman Sharma Shushmita Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 84 88 10.47070/ijapr.v12i3.3170 Effect of Shatavarichinnaruhadi Ksheerakasaya in Perimenopausal Symptoms <p>Menopause is referred to as <em>Rajakshaya </em>in Ayurveda, which is the body's transition from a <em>Pitta</em>- to a <em>Vata-</em>dominant condition. It comes under <em>Swabhavika vyadhi</em> and occurs in <em>Jara pakwa sareera</em>, which causes <em>Dhatus</em> to gradually deteriorate. Treatment of perimenopausal symptoms may benefit from medications with <em>Rasayana, Medhya, Balya, Dahasamana, Vayasthapaka</em>, and <em>Rasarakthaprasadaka</em> characteristics. A 44-year-old woman who sought treatment for hot flushes, excessive sweating, particularly at night, irritability, mood swings, numbness in the extremities, sleep disturbances, and vaginal itching is presented here. Assessment was done using Greene Climacteric Scale. Among all the symptoms, hot flushes and night sweats were the most distressing one for the subject. <em>Shatavari chinnaruhadiksheerakasaya </em>mentioned in <em>Chikitsamanjari </em>in <em>Vataraktha </em>context possess <em>Vatapittapradhana Tridoshasamana, Rasarakthapradhaka, Dahasamana, Rasayana, Medhya, Balya</em> like properties which can be beneficial in reducing the most wretched vasomotor symptoms. Apart from these, the formulation exhibits anti-oxidant, free radical scavenging, phytoestrogenic and anti-stress activity. <em>Ksheera </em>is <em>Vata pitta samana, Rasayana, Sheeta veerya, Vrishya, Ojasyam, Dhatuvardhaka</em>, and <em>Jeevaneeya.</em> For thirty days, 48ml of <em>Shatavarichinnaruhadi ksheerakasaya </em>was administered twice daily, one hour before food. The severity of symptoms particularly hot flushes and night sweats were considerably reduced after treatment. Thirty days after quitting the drug, a follow-up was conducted, and this time the severity of the symptoms was also less severe than it had been before therapy. From this case report, it is evident that <em>Shatavarichinnaruhadi ksheerakasaya </em>is effective for the management of perimenopausal symptoms especially the most disturbing vasomotor symptoms</p> Thasneem K K Giby Thomas Maya Balakrishnan Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 89 93 10.47070/ijapr.v12i3.3160 Effect of Guggulu Tiktakam Kashayam in Uterine Fibroid <p>The most common benign uterine tumours affecting women in reproductive and perimenopausal stages are fibroids or leiomyomas. There is strong evidence that estrogen and progesterone promote the growth of fibroids, despite the fact that their exact aetiology is still unclear. This is because fibroids seldom arise before menarche and retreat after menopause. The most prevalent reason for hysterectomy is fibroids. Menorrhagia, polymenorrhoea, metrorrhagia, intermenstrual bleeding, infertility, repeated abortions, pain and pressure feelings, abdominal lumps, and vaginal discharge are a few of the symptoms they exhibit clinically. In Ayurveda there is no exact correlation for uterine fibroid. Fibroids can be considered as <em>Mamsa Grandhis</em>, one among the <em>Grandhis</em> described by Charaka and Vagbhata. They increase the surface area of the endometrial tissue in the uterus when present, causing excessive bleeding, pressure feelings, dysmenorrhea, and even infertility. <em>Vata-Kapha</em> predominant <em>Tridoshas</em> have a role in the aetiology of the <em>Granthi Roga</em>, necessitating the use of <em>Vata-kaphahara</em> medicines. As <em>Granthi </em>can also be caused by <em>Mandagni,</em> in <em>Granthi chikitsa</em> we can make use of <em>Dravyas</em> that are <em>Deepana pachana. </em>According to <em>Acharya Susrutha,</em> <em>Sopha Chikitsa</em> is included in the <em>Apakwa Granthi chikitsa. </em>In <em>Mamsa granthi chikitsa,</em> <em>Shothagna, Lekhana, Chedhana, </em>and<em> Vatanulomana dravyas</em> may be utilised. <em>Asrigdara chikitsa</em> and <em>Raktapitta</em> <em>chiktsa </em>can be used to treat fibroids when heavy, prolonged menstrual cycles are present. A 38 year old lady was presented with complaints of heavy, prolonged bleeding during menstruation along with lower abdomen pain. On USG she was diagnosed with uterine fibroids. <em>Guggulu tikitakam kashayam</em> was given for 3 months and after follow up symptoms were evaluated. She was relieved from prolonged heavy bleeding during menstruation and lower abdomen pain. From this case report, it is evident that <em>Guggulu tiktakam kashayam </em>is effective in uterine fibroids</p> Swathy Sunil Giby Thomas Maya Balakrishnan Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 94 96 10.47070/ijapr.v12i3.3159 Comprehensive Review of Kaphaja Yonivyapath: Etiology, Diagnosis and Management Strategies <p>A family's health is guaranteed by a healthy woman. Ayurveda and contemporary medicine have both discussed the idea of a healthy yoni at various stages of a woman's life, from adolescence to menopause. These days, vaginal infections are a major concern for people of all ages and socioeconomic backgrounds. Because women have a special role of giving birth, gynecological illnesses have gained enormous relevance in the medical field. The majority of gynecological problems are included under the word "<em>Yonivyapad</em>," which is used in Ayurveda to refer to women's health care. Among 20 <em>Yoni Vyapath’s Kaphaja yonivyapath</em> is the one which is due to vitiation of <em>Kapha, </em>this vitiated <em>Kapha</em> reaches the <em>Yoni</em> <em>Pradesha</em> causes signs and symptoms like <em>Kandu</em>, <em>Picchila</em> <em>Srava</em> and <em>Alpa</em> <em>Vedana </em>as well as<em> Sthanika </em>and<em> Sarvadaihika Kapha Prakopa Laxana</em>. The treatment of <em>Kaphaja</em> <em>Yonivyapath</em> explained in classic as <em>Kapha</em> <em>hara</em> <em>Dravyas</em> and <em>Shodhana</em> <em>Chikitsa</em> mainly <em>Vamana</em> is indicated. This can be correlated with vulvovaginitis which is caused due to bacterial vaginosis, moniliasis and trichomans vaginalis. In this review an attempt has been made in this work to provide a conceptual analysis that covers nearly all of the <em>Nidana</em>, <em>Samprapti</em> and <em>Chikitsa</em> of <em>Kaphaja</em> <em>Yoni Vyapad</em> according to both Ayurveda and modern.</p> Ashok Lamani Ramadevi G Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 97 101 10.47070/ijapr.v12i3.3123 A Case Report on Alcohol Withdrawal Syndrome <p>Heavy drinkers who abruptly cut back on their alcohol intake or give it up entirely risk experiencing alcohol withdrawal. The warning signs and symptoms include agitation, anxiety, irritability, and mild to moderate tremors. Seizure, hallucinations, delirium tremens are the most severe withdrawal symptoms. These symptoms arise from abnormalities in brain chemistry brought on by alcohol, which leads to an excess of neuronal activity when the alcohol is stopped. Ayurveda is a holistic approach which not only takes body into consideration but also mental status. <em>Madatyaya</em> is a wide term explained in our classics, while explaining <em>Madya</em>, <em>Acharaya</em> told that it has properties opposite to that of <em>Ojus</em>, so these substances causing depletion to our body resources can be correlated to <em>Madatyaya.</em> So it’s a case report on alcohol withdrawal symptoms and its effective management using Ayurvedic treatment modalities.</p> Divin V Suneeshmon M S Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 102 106 10.47070/ijapr.v12i3.3164 An Ayurvedic Perspective About Duchenne Muscular Dystrophy <p>Duchenne muscular dystrophy is a neuromuscular disease. This is an X-linked recessive disease caused by mutations in the dystrophin protein gene located on the short arm of the X chromosome, in the Xp21 region. It causes progressive muscle weakness due to wasting of muscle fibers. It causes loss of ability to stand, walk, and move before age 10; most patients die in their 20s. Since there is no specific treatment in any medical system and the prognosis of the disease is uncertain, if we start treatment at an early stage, children with DMD can walk, it can slow or stop progressive muscle degeneration. DMD cannot be directly related to a single disease in Ayurveda. Most major neuromuscular disorders are determined by <em>Vata dosha</em>. In Ayurveda, this pathogenesis can be clearly understood by the concept of <em>Adibala Pravrutta Vyadhi</em> (genetic disease). Here the pathogenesis is due to <em>Beeja Bhagavayava Dusti </em>(partial chromosomal defect) leading to <em>Mamsa Vata Dushti</em>.</p> Ashwini A. Patil Rutuja Rahul Kate Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 107 110 10.47070/ijapr.v12i3.3156 Severe Clinical Insomnia Management with Ayurvedic Protocol - A Case Report <p>Insomnia is characterized by inability to sleep or lack of sleep. Severe clinical insomnia is a highly prevalent health concern faced by a wide majority of people across the globe due to the rise in stressful external environments. Often such cases require long term use of sedative hypnotics or tranquilizers which are habit forming. Ayurveda identifies insomnia as <em>Nidranasa </em>and is a disease which is caused predominantly by <em>Vata Pitta</em> increase and a dip in <em>Kapha</em> levels. Ayurvedic treatment protocol involves internal medication and topical procedures like <em>Shirodhara</em> and <em>Abhyanga.</em> This case report is intended to throw light to a positive outcome of Ayurvedic treatment protocol in severe clinical insomnia. A 34-year-old male presented with symptoms of severe clinical insomnia assessed by Insomnia Severity Index (ISI) associated with obesity and had a history of consuming hypnotics. The treatment protocol included <em>Dhanyamladhara, Udvartana, Takradhara, Abhyanga</em> and <em>Shirodhara </em>along with disease specific internal medicines. The ISI score before treatment of 26 came down to 1 after treatment and was maintained during 3 months follow up. This displays the complete remission of the disease without the use of habit-forming internal medication.</p> Shilpa Thengil Ambili Krishna Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 111 115 10.47070/ijapr.v12i3.3173 Varieties of Classical Drug Kadamba <p><em>Kadamb</em> an indigenous plant described in classical texts of Ayurved has a wide range of therapeutic potential. In Charak Samhita, it has been classified in the group of drugs indicated in the management of pain (<em>Vednasthapan Mahakashya</em>). Among various indications, it has been reported to be used in the treatment of vitiated semen, as an astringent in healing of fractured wounds, hemorrhagic conditions, dyslipidaemia, diseases of female genital tract, as complexion promoting and alexipharmic. In classical texts, at least four varieties of <em>Kadamb</em> have been described. There has always been some controversy regarding botanical identity of different varieties of <em>Kadamb</em> described in classical texts. Present paper is a serious attempt towards establishment of botanical identities of different types of <em>Kadamb</em> described in classical text of Ayurved on the basis of exploration of literature substantiated by observations of field survey.</p> Singh Sanjeev Kumar Mishra Hari Shanker Agarwal Ajay Shukla Anil Kumar Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 116 120 10.47070/ijapr.v12i3.3174 Review on the Effect of An Ayurvedic Management Protocol in Chronic Obstructive Pulmonary Disease <p>Considering the similarities noticed in the etiology and clinical features, COPD can be correlated to <em>Tamaka shvasa </em>among the<em> Pranavaha srotodushti vikara</em>, a condition where <em>Pitta</em> is involved along with <em>Kapha</em> and <em>Vata. Rasayana </em>is the main intervention in such a chronic disease and considering the<em> Doshas </em>and<em> Rasayana, Virecana </em>is the best preparatory<em> Shodhana </em>here to be administered for the patients. In Ayurveda, drug is denoted by the term <em>‘Bheshaja</em>’ which is defined as the substance through which we can overcome the fear of disease. The ‘<em>Upakarana</em>’ which helps physician for maintaining the healthy condition or to alleviate disorders is said to be <em>Bheshaja</em>. Physician accomplishes the object ‘<em>Vikara shamana’, </em>by giving the appropriate <em>Bheshaja</em> according to different stages and conditions of the patient and disease. According to Ayurveda, action of a drug is based on its <em>Guna, Virya, Vipaka </em>and<em> Prabhava</em>. Fate of the drug always depends on <em>Rasapancaka</em> and it goes in line with modern pharmacodynamics. Besides that, the drug action also depends on the action of <em>agni</em> on that particular drug. In this article, a management protocol review on Chronic Obstructive Pulmonary Disease was carried out. The protocol selected and reviewed was <em>Dipana</em> with <em>Panchakola curna</em> in hot water, <em>Snehapana</em> with <em>Kantakari ghrta</em>, <em>Abhyanga</em> with <em>Tila taila</em> followed by <em>Ushmasveda</em>, <em>Virecana</em> with <em>Vidangatanduladi curna </em>and finally <em>Pippali Vardhamana rasayana</em>.</p> Aswathy M Jithesh M Copyright (c) 2024 International Journal of Ayurveda and Pharma Research 2024-04-04 2024-04-04 121 126 10.47070/ijapr.v12i3.3169